Drug excretion involves?

Drug excretion involves?

• A. Metabolism of drug to active metabolites
• B. Removal of drug from the body; kidneys are key
• C. Bioactivation in liver
• D. Storage in adipose tissue

Answer: (B)

Excretion is the process of removing a drug from the body. The kidneys are the primary route for this elimination, filtering the blood and delivering drug and metabolites into urine for removal. While other routes (bile, lungs, sweat) exist, renal excretion is the central mechanism for most drugs. The other ideas describe metabolic changes, not removal: metabolism or biotransformation in the liver often converts drugs into more water-soluble forms to prepare for excretion, and bioactivation refers to activating a prodrug in the liver. Storage in adipose tissue describes distribution and potential storage, not elimination from the body.

Excretion is the process of removing a drug from the body. The kidneys are the primary route for this elimination, filtering the blood and delivering drug and metabolites into urine for removal. While other routes (bile, lungs, sweat) exist, renal excretion is the central mechanism for most drugs.

The other ideas describe metabolic changes, not removal: metabolism or biotransformation in the liver often converts drugs into more water-soluble forms to prepare for excretion, and bioactivation refers to activating a prodrug in the liver. Storage in adipose tissue describes distribution and potential storage, not elimination from the body.